“What we are learning is that virtually every adult disease we have is going to be linked to epigenetic origins,” says pediatrician Dr. Paul Winchester, who conducted a study that linked the pesticide atrazine in drinking water with birth defects.
Winchester discovered that atrazine had epigenetic effects. Epigenetics is the theory that environmental factors, such as diet, lifestyle choices and pesticides can impact the health of people who are exposed to them and also their descendants. Human DNA, according to epigenetics, is not unchangeable; it can be altered by such environmental factors. Epigenetic changes can be imprinted on the DNA of a fetus during pregnancy according to Winchester.
“If it is fixed then, it becomes inheritable and it becomes a trait that you can pass on to the next generation and the next and next.”
For the atrazine study, Winchester’s team used advanced technology to detect epigenetic changes—and resulting negative health impacts—over several generations of rats whose mothers were exposed to atrazine.
Common sense would seem to dictate that fewer negative health outcomes would be seen with subsequent generations. But the study found the opposite: There were more abnormalities and diseases in later generations of rats. The first generation of rats whose mother was exposed to atrazine weighed less than a group of control rats. The second generation weighed less but also had incidences of testicular disease and breast cancer. The third generation suffered the most problems, according to Winchester.
“We waited until the third generation, where no direct exposure (to atrazine) occurred, to ask if these epigenetic effects could be inherited, because there is no mechanism, no exposure, no toxicity that could explain a change in disease rates in the third generation. We found that 50 percent of offspring had multiple diseases, emotional and physical problems, hyperactivity, abnormal sperm, and premature puberty.”
“The most alarming (finding) to me is that almost every chemical tested including atrazine reduced fertility in the third generation of offspring.”
Winchester called the discovery of the link between chemicals like pesticides and epigenetic changes leading to disease “the most important next discovery in all of medicine.”
“This is a huge thing that is going to change how we understand the origin of disease. But a big part of that is that it will change our interpretation of what chemicals are safe. In medicine I can’t give a drug to somebody unless it has gone through a huge amount of testing. But all these chemicals haven’t gone through anything like that. We’ve been experimented on for the last 70 years, and there’s not one study on multigenerational effects.”
Winchester also co-authored a study published recently in Environmental Health that found detectable levels of glyphosate in the urine of 93 percent of a group of pregnant women in Central Indiana. The levels of glyphosate detected correlated with shorter pregnancies.
Again, the study raises concerns of possible epigenetic effects leading to disease in later generations.
“We are the first researchers in the U.S. to report that virtually every pregnant mother has glyphosate in her body at the time that she is creating fetal (epigenetic) imprints in her baby,” Winchester said.
“In the current paradigm, which is definitely pro-business, the only thing companies have to prove is that it doesn’t kill you if you drink it or take a big dose of it.”
He sees a potentially catastrophic outcome resulting from the epigenetic damage caused by pesticides.
“Every one of the chemicals tested so far produces infertility, and the industrial world has reached the lowest level of fertility on record. We are below replacement levels in most industrialized countries including the U.S.This is looking at your own species extinction.”
Winchester lays the blame at the feet of the U.S. Environmental Protection Agency, which doesn’t consider epigenetic or generational effects of chemicals, and the pesticide and chemical manufacturers like Monsanto.
“They can sell all the Roundup they want, but if it’s in me they are going to have to pay for that. Every molecule that I find is on them … What I want to know is: has my fetus had altered DNA imprinting because of this chemical? I have a right to know that. If we are going to have to wait 75 years to find out if my grandchildren are going to be affected by it, I think somebody has to pay. They better put a fund together. I want somebody’s head to roll. I don’t think that the EPA and Monsanto get to walk away.”